Creighton went head-to-head with DePaul on Tuesday night. The Jays were off to a good start with the first points on the board, courtesy of Steven Ashworth. Jamiya Neal accounted half of Creighton's points as they led 16-7.

Creighton took the lead with 19:43 remaining in the first half and did not relinquish it. Neal led with 12 points in the first half to help put the Bluejays up 31-19 at the break. Creighton extended its lead to 45-23 during the second half, fueled by a 10-2 scoring run. Kalkbrenner scored a team-high 10 points in the second half.

DePaul faces the Xavier Musketeers after Jorie Allen scored 22 points in DePaul's 92-71 loss to the Creighton Bluejays.