Chiefs vs Colts betting line & prediction
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Preview the Week 12 matchup between the Indianapolis Colts and Kansas City Chiefs with predictions, odds, over/under, spread, betting lines and more.
Oct 5, 2025; Indianapolis, Indiana, USA; Indianapolis Colts safety Cam Bynum (0) high fives cornerback Charvarius Ward (7) after an interception against the Las Vegas Raiders during the second quarter at Lucas Oil Stadium. / Trevor Ruszkowski-Imagn Images
Colts HC Shane Steichen had good news to share regarding the team's injury report for Sunday's showdown with Chiefs
Patrick Mahomes has never lost three consecutive regular-season starts, and the Chiefs haven't been below .500 through 11 games since 2012, but both of those streaks are at risk Sunday when Kansas City hosts the Indianapolis Colts in a crucial Week 12 showdown.
The dads, Brads and Chads might need to reverse course if they want any hope of the Kansas City Chiefs making the playoffs. It’s been a rollercoaster of a season for the Chiefs thus far, currently sit
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Kansas City Chiefs OC Matt Nagy delivers a 'loud and clear' powerful message before matchup vs. Colts
"We're in a place right now where we understand the sense of urgency…I will make it loud and clear, there's no other people or players around that I'd rather be around to do this thing the right way," offensive coordinator Matt Nagy told reporters on Thursday.
The Colts are trying to stay atop the AFC standings while securing a key 9-2 record. As for the Chiefs, they're trying to avoid missing the playoffs for the first time with Patrick Mahomes as the quarterback. Expect fireworks when the Colts and Chiefs collide for a high stakes AFC matchup this Sunday.