Researchers have revealed a novel mechanism by which the chromatin remodeler brahma-related gene 1 (Brg1) regulates Group 2 ...
Chromatin remodelers are ATP-dependent motor proteins that dynamically reorganize chromatin architecture, playing essential roles in gene expression, development, and immune function. Dysregulation of ...
The INO80 chromatin remodelling complex has various roles in genome maintenance, acting via nucleosome sliding and H2A.Z removal. Here, it is shown to also facilitate the bypass of DNA lesions during ...
Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, determines which genetic instructions are activated. When this fails, the wrong ...
Novel targeted therapies for ARID1A-mutant and CDA-resistant cancers highlighted MENLO PARK, CA / ACCESS Newswire / October 27, 2025 /Edison Oncology, a clinical-stage biopharmaceutical company ...
Our cells are usually frantically working to sustain life. Part of this work includes dividing, a process that creates more cells to support our growth when we are children or to replace old, worn-out ...
Izpisua Belmonte, PhD, Altos Labs, advocates a disease-agnostic approach, but first, he said, “we must understand the mechanism, something that is core to the cell.” ...
Epigenetics plays a critical role in human health by regulating gene expression without the direct modification of DNA sequence. Aberrant epigenetic modifications mediated by changes in DNA and ...
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