DNA helicases are motor proteins that translocate along nucleic acids to separate complementary strands, a step essential for replication, repair and recombination. By unwinding duplex DNA and ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Intracellular DNA can become damaged and/or distorted through a multitude of endogenous and exogenous sources (e.g., post-replication mismatches, base oxidation, cyclobutane pyrimidine dimers) 1,2.

For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the DNA repair enzyme Werner helicase, demonstrated early signals of efficacy ...

Researchers at the Francis Crick Institute have uncovered how the double helix structure of DNA is opened to allow DNA replication. The work could lead to further studies to better understand this ...

A research team led by Dr. Yuanliang Zhai from the School of Biological Sciences, The University of Hong Kong (HKU), and his collaborators from The Hong Kong University of Science and Technology ...

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections - and, alas, extraordinarily difficult to target with drugs. Now, new ...

Scientists at the University of Leicester have captured the first detailed “molecular movie” showing DNA being unzipped at the atomic level – revealing how cells begin the crucial process of copying ...

RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors This class of ...