Collectively, these results unveil a key role for D-serine in the dopaminergic neuromodulation of glutamatergic transmission and PFC activity, findings with clear relevance to the pathogenesis and ...

Glovadalen, a novel D1 receptor positive allosteric modulator, is linked to improve OFF time in patients with Parkinson’s ...

There are three dopaminergic pathways, namely the striatonigral pathway (substantia nigra to caudate and putamen), the mesolimbic pathway (ventral tegmental area of midbrain to limbic areas of basal ...

Cobenfy represents a breakthrough schizophrenia treatment with a novel mechanism, but limited long-term data requires ...

A new study shows how a dopamine circuit between two brain regions enables mice to extinguish fear after a peril has passed. Dangers come but dangers also go and when they do, the brain has an ...

Focal cortical dysplasia (FCD) type 2 is a congenital malformation of the cerebral cortex that is often associated with difficult-to-treat epilepsy. In the affected areas, nerve cells and their layer ...

Exposure to stress activates a group of natural physiological and cerebral responses that orchestrate the necessary behavioral changes for facing threats to one’s life, such as fleeing or fighting ...

What neural and behavioral mechanisms allow mice to identify food sources, navigate toward them, and initiate consumption? A research team led by Prof. Zhang Yunfeng from the Institute of Zoology of ...