Heterochromatin, sometimes known as the “dark side of the genome,” is a poorly studied fraction of DNA that makes up about half of our genetic material. For more than 50 years scientists have puzzled ...
Longitudinal tracing of on-treatment plasma Epstein-Barr virus DNA as a biomarker for real-time dynamic risk monitoring in patients with nasopharyngeal carcinoma: The EP-SEASON study. Nivolumab ...
Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes. Pericentric heterochromatin ...
Chromosomes are composed of functionally distinct domains separated by chromatin boundaries. In the August 10 Science, Noma et al. define the boundaries of the heterochromatin domain at the ...
In mouse models, the aberrant interaction of LINE-1 RNA and SUV39H1 led to heterochromatin erosion and the loss of tissue specific genetic programs. When LINE-1 RNA was depleted in human progeroid ...
An international team of almost one hundred scientists has uncovered the complete, gap-free human genome by deciphering the remaining and hitherto unknown sequences – opening the door for novel ...
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