T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

Immunotherapies – treatments that aim to make the body's natural immune system more effective – are becoming more widely used ...

When immune cells strike, precision is everything. New research reveals how natural killer and T cells orchestrate the release of toxic granules—microscopic packages that destroy virus-infected or ...

Three scientists have been awarded the 2025 Nobel prize in physiology or medicine for discovering how the body stops its own immune system from turning against itself. Shimon Sakaguchi from Osaka ...

Researchers have identified a target that may improve the response of CAR T-cell therapy, a treatment for patients with ...

Researchers discovered a way to keep T cells from wearing out during the fight against cancer, and the approach could make immune-based treatments far more powerful. They found that tumors use a ...

For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular ...

While most patients initially respond to CAR-T cell treatment, responses often are not durable and subsequent lines of immunotherapy show diminishing success. In this study, we investigated the ...

Just before the pandemic took center stage in 2020, scientists at a T cell memory conference convened to discuss a less than traditional topic: nomenclature. Prior to the event, the workshop ...