SARS-CoV-2 infection extends beyond the respiratory epithelium to target the vascular endothelium through ACE2 binding. This leads to activation of endothelial cells, disruption of barrier function ...

A polygenic risk score (PRS) based on genes associated with endothelial cell function identifies patients at a higher risk of coronary artery disease, according to a new study. The risk score, which ...

Sepsis, a life-threatening systemic inflammatory response triggered by infection, has long challenged clinicians with its persistently high mortality (up to 40-50% in septic shock). At the heart of ...

The glycocalyx emerges as an active endothelial system whose structure, metabolism, and shear-dependent regulation integrate mechanical forces with vascular signaling. Disruption of this system ...