The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, ...
Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...
Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...
The human body naturally produces opioid-like substances, such as endorphins, which block the perception of pain and increase the feeling of well-being. Similarly, opioid drugs, including morphine or ...
We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of nociceptors. Biopsy samples of inflamed colonic mucosa from patients and mice with colitis released ...
Depression is a condition affecting millions across the globe. However, efficient drugs with minimal adverse effects are scarce. Now, researchers have reported how KNT-127, a delta opioid receptor ...
Brain volume and function are altered in individuals with opioid use disorder, a new Yale study finds. Using magnetic resonance imaging (MRI) and functional MRI (fMRI), researchers observed the ...
July 3 (UPI) --U.S. researchers said Wednesday that they have identified a new drug that could make inroads on the devastation caused by opioids -- by supercharging naloxone, branded as Narcan, the ...
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