Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize ...
For a monovalent species, a simple calculation that does not assume partitioning of the ionized species in the oil phase can provide an accurate estimate of the distribution coefficient.
The n-octanol is considered a good mimic of phospholipids membrane characteristics because its nature is amphiphilic 3. Among other physicochemical properties, lipophilicity plays a key role for ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results