An error in a gene, a mutation, can cause a disease, but the relationship between the genome of an organism and its physical characteristics, and exactly how genetic ...
Our DNA contains thousands of genes, and it is critical that the correct genes are expressed in the right places at the proper time. Our cells have a variety of ways to control gene expression, one of ...
Biological rhythms aren't just for sleep. In the tiny worm C. elegans, researchers in the Grosshans lab and the Computational ...
The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology
Technologies such as DNA microarrays, RNA sequencing (RNA-seq), and chromatin immunoprecipitation-sequencing (ChIP-seq) have enabled comprehensive analyses of transcription factor-target genes. By ...
Splicing mainly takes place during transcription. Catalysis is achieved through the stepwise assembly of the spliceosome onto nascent RNA. Recent in vivo studies have shown that the catalytic ...
The central dogma of molecular biology describes the flow of genetic information. It was first described by Francis Crick in 1956 as one-way traffic: as: "DNA makes RNA and RNA makes protein." A ...
Researchers from the A*STAR Institute of Molecular and Cell Biology (IMCB) have identified Nr1h2, a critical transcription factor essential for early embryo development. Published in Nature ...
DNA, the long polymer curled up inside our cells, is often described as the instructions for life. But those instructions are stored in DNA’s chemical code, and reading that code requires the ...
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