Ubiquitination of mammalian seven-transmembrane-spanning receptors facilitated by β-arrestin is an agonist-stimulated modification that leads to receptor degradation in lysosomal compartments. In ...

Tail-anchored (TA) membrane proteins are targeted to the endoplasmic reticulum (ER) post-translationally by the guided entry of TA proteins (GET) pathway; this involves the formation of a complex ...

This is a preview. Log in through your library . Abstract We have investigated the topology of the α and δ subunits of the nicotinic acetylcholine receptor (AChR) from mammalian muscle synthesized in ...

A crucial step in preclinical drug development is the confirmation of the novel therapeutic molecule's specific binding to the targeted protein. Transmembrane proteins (TPs) like ion channels, ...

This study demonstrates the power of a genetic selection to identify a variant virus that uses a new retroviral receptor protein. We screened a random peptide library within the receptor-binding ...