Protease mechanisms | Learn Science at Scitable - Nature
Protease mechanisms Protease mechanisms Polypeptides can be cleaved either chemically or enzymatically. Enzymes that catalyse the hydrolytic cleavage of peptide bonds are called …
Proteases - Latest research and news | Nature
Dec 18, 2025 · Proteases articles from across Nature Portfolio Atom RSS Feed Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids …
Serine Protease, Enzyme Catalysis | Learn Science at Scitable
Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and …
A novel alkali and thermotolerant protease from Aeromonas spp ...
Oct 29, 2024 · Protease enzymes, in particular, have proven to be cost-effective, stable, and compatible alternatives to traditional chemical processes in both industrial and environmental …
Data-driven protease engineering by DNA-recording and ... - Nature
Jul 1, 2025 · Substrate-specific proteases have an enormous potential in the life sciences, but tailoring their specificity remains challenging. Here, the authors describe a data-driven …
Multitarget mechanism of MYC inhibition by the bacterial lon …
Feb 25, 2025 · The bacterial Lon protease was recently identified as a potent inhibitor of human MYC, with effects on MYC-dependent gene expression and therapeutic efficacy in models of …
Targeting proteases: successes, failures and future prospects
The status of human protease research and prospects for future protease-targeted drugs are reviewed here, with reference to some key examples where protease drugs have succeeded …
Substrate recognition and cleavage mechanism of the monkeypox …
Apr 22, 2025 · Structural and biochemical studies of the monkeypox virus core protease show that it exists as an active homodimer and indicate that the substrate-binding sites of core proteases …
Lon protease 1-mediated metabolic reprogramming promotes the ...
Feb 19, 2025 · Lon protease 1 (LONP1) is an ATP-dependent protease located in the mitochondrial matrix and plays a crucial role in regulating mitochondrial proteostasis, …
Production optimization of a thermostable alkaline and detergent ...
Apr 16, 2025 · Our results suggest that this thermostable, alkaline, and detergent-biocompatible protease could be a promising additive for eco-friendly use in detergent industries.