Up to 20% of patients with chronic limb-threatening ischemia are not candidates for arterial revascularization. Transcatheter arterialization of the deep veins is a possible alternative approach. New research findings are summarized in a short video. https://nej.md/3KbRNpS | The New England Journal of Medicine

KJ Muldoon, the infant with a life-threatening metabolic disorder who received a pioneering gene-editing therapy at Children’s Hospital of Philadelphia, went home Tuesday after 307 days at the hospital, CHOP announced. KJ risked irreparable brain damage from his condition, called severe carbamoyl phosphate synthetase 1 (CPS1) deficiency, in which his liver could not process protein. CPS1 deficiency is deadly in more than half of cases. Doctors at CHOP rapidly developed within six months an exper